(Windows) Improved performance of Prism file opening on Windows 7 under non-admin user account. (Windows) Improved Prism's ability to open very large projects. Spearman correlation (computation of exact P values) nearly instant with only one pair of tied values (analysis speed proportional to the number of tied values). Mixed-effects model used in repeated measures ANOVA and nested analyses ~10x faster. 
Kruskal-Wallis exact test twice as fast.Repeated measures one-way ANOVA with equal number of values in each group ~20x faster.Asymmetric (Profile Likelihood) confidence intervals are twice as fast
Drastically faster computation of the following analyses (by improving algorithms and by using multiple processor cores):. Reports the direction of the mean of differences in 'Paired t test’ results sheet (either "A-B" or "B-A"). (Windows) Enabled the command in the contextual menu to apply a pattern fill to a grouped interleaved scatter graph with bars. Parts of Whole graph titles now come from the column title rather than the data table name. Made the "Lines with text" drawing object more usable by adding more predefined choices for "texts". Scatter plots now show a line at the median of the data set by default. Choose a default plot style for various kinds of graphs. Changed the automatic initial value for HillSlope to -1.0 for the variable slope inhibitory dose-response curve. Dunn's test now reports z ratio so you can compare with other programs or texts. (Mac) Enabled multiple selections (using Shift or Command key) of data sets in the 'Data Sets on Graph' tab of the 'Format graph' dialog for graphs from Grouped and Contingency graph families. (Mac) Enabled the script command ExportAllPDF that exports all the graphs (or layouts) into a single multipage file. all users library (for all users on a Mac): /Library/Application Support/GraphPad/Prism/. user library: ~/Library/Application Support/GraphPad/Prism/. (Mac) You (or your IT person) can now place the Prism Configuration File (prism-config.xml) into additional locations:. "Dunnett T3" test can be used to compare the mean of each column with the mean of every other column after nonparametric one-way ANOVA. Added an option to calculate profile likelihood CIs even when a fit is ambiguous in the 'Confidence' tab of the 'Parameters: Nonlinear Regression' dialog. The correlation matrix analysis can now generate a heatmap of Pearson's correlation coefficient (r) values. 
New "auto" color for annotations and labels that switches between white and black depending on the background color. New (useful!) color schemes including a "Colorblind Safe" color scheme, appropriate for presentation and publication of data to a broad audience. The colors in this scheme were designed to be distinguishable by individuals with a variety of different color vision deficiencies. Complete Release Notes for Prism 8.1.0 New Features
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